Stromal-Immune interactions in the body cavities

Scanning Electron Micrograph showing a murine omentum 18h following intra-peritoneal thioglycollate injection A FALC is pictured on the surface of the mesothelium.

We recently defined novel populations of FALC cover cells (See Jackson-Jones, Immunity 2020); these cells are mesothelial in origin and are spatially positioned over the surface of fat associated lymphoid clusters. FALC cover cells have specialised immune functions including recruitment and modulation of immune cells and the response to viruses. Ongoing work is confirming whether these cells have comparable functions within the pleural cavity and what their role is during infection, inflammation & cancer.

This work was undertaken initially when Lucy was a post-doctoral researcher in the laboratory of Dr Cecile Benezech at the University of Edinburgh.