Investigating the early inflammatory events occurring at the initiation of mesothelioma within the pleural cavity

FALC of the Omentum
Fat associated lymphoid cluster within a body cavity adipose tissue

Investigations are underway to try and unpick the inflammatory cascade that is initiated within the pleural cavity following arrival of long, bio-persistent fibres such as asbestos and multi-walled carbon nanotubes.  We aim to determine the stromal-immune micro-environment during pleural cavity inflammation in order to better understand how mesothelioma develops & can be targeted.

This project was initiated as a PhD studentship funded by the Sir John Fisher Foundation and is now part of a wider CRUK programme grant in collaboration with Prof Marion MacFarlane at the University of Cambridge & Prof Daniel Murphy & Dr Seth Coffelt at the University of Glasgow.

These in vitro & in vivo studies are complemented by clinical investigations quantifying the immune environment of pleural fluid isolated from patients with mesothelioma in a collaborative project with Dr Claire Rooney. This study if funded by a Mesothelioma pump-priming grant from the Asthma & Lung UK.