Research
Investigating the early inflammatory events occurring at the initiation of mesothelioma within the pleural cavity
![FALC of the Omentum](http://wp.lancs.ac.uk/jackson-jlab/files/2020/03/Omentum-scaled-up-300x300.jpeg)
Investigations are underway to try and unpick the inflammatory cascade that is initiated within the pleural cavity following arrival of long, bio-persistent fibres such as asbestos and multi-walled carbon nanotubes. We aim to determine the stromal-immune micro-environment during pleural cavity inflammation in order to better understand how mesothelioma develops & can be targeted.
This project was initiated as a PhD studentship funded by the Sir John Fisher Foundation and is now part of a wider CRUK programme grant in collaboration with Prof Marion MacFarlane at the University of Cambridge & Prof Daniel Murphy & Dr Seth Coffelt at the University of Glasgow.
These in vitro & in vivo studies are complemented by clinical investigations quantifying the immune environment of pleural fluid isolated from patients with mesothelioma in a collaborative project with Dr Claire Rooney. This study if funded by a Mesothelioma pump-priming grant from the Asthma & Lung UK.