Improving the quality of efficacy and mechanisms evaluation (EME) studies

Logo of the MRC Hubs for Trials Methodology Research.

The workshops were funded by the MRC Network of Hubs for Trials Methodology Research. HTMR Hubs which supported the workshops included North West HTMR, MRC CTU and Oxford CTSU.

Investigators: Tom Palmer (North West HTMR), Richard Emsley (North West HTMR), Ian White (MRC CTU), Sabine Landau, Jonathan Cook (Oxford CTSU), Louise Brown (MRC CTU), Carrol Gamble (North West HTMR).

EME Workshop

23rd March 2017, University of Manchester

Workshop programme:

  • Aims and objectives of the NIHR EME Programme – Louise Brown
  • Examples of EME studies – Jonathan Cook and Richard Emsley
  • Introduction to some helpful statistical modelling concepts – Tom Palmer
  • Design and analysis issues for EME studies – Sabine Landau and Richard Emsley
  • Group work: EME studies – 4 examples
  • Meet the experts: Are you planning to apply for funding for a study that requires EME expertise? Attendees can ask advice on EME aspects of their proposals.

Materials available on request.

EME Training day

8th May 2018, UCL

Training day programme:

  • Instrumental variables: lecture and Stata practical – Tom Palmer
  • Non-compliance using inverse probability weighting (IPW): lecture and Stata practical – Ian White
  • Introduction to mediation: lecture and Stata practical – Richard Emsley

Materials available on request.


Dunn G, Emsley R, Liu H, Landau S, Green J, White I, Pickles A. Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme. Health Technology Assessment 2015;19(93).


Tom Palmer,