{"id":323,"date":"2021-05-24T21:04:03","date_gmt":"2021-05-24T21:04:03","guid":{"rendered":"https:\/\/wp.lancs.ac.uk\/mortlab\/?p=323"},"modified":"2021-05-24T21:04:03","modified_gmt":"2021-05-24T21:04:03","slug":"msc-by-research-mres-projects-available","status":"publish","type":"post","link":"https:\/\/wp.lancs.ac.uk\/mortlab\/2021\/05\/24\/msc-by-research-mres-projects-available\/","title":{"rendered":"MSc by research (MRes) projects available"},"content":{"rendered":"\n<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?via=lab_mort\" class=\"twitter-share-button\">Tweet<\/a><\/div>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">The Mort Lab are looking for self-funded MSc by Research (MRes) students to develop new DNA damage biosensors or to investigate the role of mechanical forces in melanocyte development. <\/span><\/p>\n<p><strong>MSc Project 1: Developing multicistronic biosensors of proliferation and DNA damage.<\/strong><\/p>\n<p>Help us generate next generation biosensors that allow us to monitor DNA damage status and cell cycle stage using the Fucci <sup>1-3 <\/sup>(fluorescence ubiquitination cell cycle indicator) system in living cells as tools for cancer research.<\/p>\n<p><strong>MSc Project 2: Investigating the role of mechanical forces on melanocyte and melanoblast behaviour.<\/strong><\/p>\n<p>Melanoblasts are able to migrate and proliferate extensively as they colonise the expanding epidermis <sup>4<\/sup> during embryonic development. But how do the physical forces exerted on the tissue influence this behaviour? This project will build tissue and cell stretching devices using Lego<sup>5<\/sup> to investigate the influence of physical forces on melanocyte behaviour.<\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">Contact: r.mort@lancaster.ac.uk<\/span><\/p>\n<p>1. Sakaue-Sawano A. et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132:487-98 (2008).<\/p>\n<p>2. Mort, R. L. et al. Fucci2a: A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice. Cell Cycle 13, (2014).<\/p>\n<p>3. Sakaue-Sawano A. et al. Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle. Mol. Cell <span class=\"cit\">2;68(3):626-640.e5 <\/span>(2017).<\/p>\n<p>4. Mort, R. L. et al. Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nat. Commun. 7, (2016).<\/p>\n<p>5. Boulter E. et al. Cyclic uniaxial mechanical stretching of cells using a LEGO\u00ae parts-based mechanical stretcher system. J Cell Sci 133 (1): jcs234666, (2020).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Mort Lab are looking for self-funded MSc by Research (MRes) students to develop new DNA damage biosensors or to investigate the role of mechanical forces in melanocyte development. MSc Project 1: Developing multicistronic biosensors of proliferation and DNA damage. Help us generate next generation biosensors that allow us to monitor DNA damage status and &hellip; <a href=\"https:\/\/wp.lancs.ac.uk\/mortlab\/2021\/05\/24\/msc-by-research-mres-projects-available\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;MSc by research (MRes) projects available&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1209,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-323","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/users\/1209"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/comments?post=323"}],"version-history":[{"count":2,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323\/revisions"}],"predecessor-version":[{"id":325,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323\/revisions\/325"}],"wp:attachment":[{"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/media?parent=323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/categories?post=323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/tags?post=323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}