{"id":323,"date":"2021-05-24T21:04:03","date_gmt":"2021-05-24T21:04:03","guid":{"rendered":"https:\/\/wp.lancs.ac.uk\/mortlab\/?p=323"},"modified":"2021-05-24T21:04:03","modified_gmt":"2021-05-24T21:04:03","slug":"msc-by-research-mres-projects-available","status":"publish","type":"post","link":"http:\/\/wp.lancs.ac.uk\/mortlab\/2021\/05\/24\/msc-by-research-mres-projects-available\/","title":{"rendered":"MSc by research (MRes) projects available"},"content":{"rendered":"\n
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The Mort Lab are looking for self-funded MSc by Research (MRes) students to develop new DNA damage biosensors or to investigate the role of mechanical forces in melanocyte development. <\/span><\/p>\n

MSc Project 1: Developing multicistronic biosensors of proliferation and DNA damage.<\/strong><\/p>\n

Help us generate next generation biosensors that allow us to monitor DNA damage status and cell cycle stage using the Fucci 1-3 <\/sup>(fluorescence ubiquitination cell cycle indicator) system in living cells as tools for cancer research.<\/p>\n

MSc Project 2: Investigating the role of mechanical forces on melanocyte and melanoblast behaviour.<\/strong><\/p>\n

Melanoblasts are able to migrate and proliferate extensively as they colonise the expanding epidermis 4<\/sup> during embryonic development. But how do the physical forces exerted on the tissue influence this behaviour? This project will build tissue and cell stretching devices using Lego5<\/sup> to investigate the influence of physical forces on melanocyte behaviour.<\/p>\n

Contact: r.mort@lancaster.ac.uk<\/span><\/p>\n

1. Sakaue-Sawano A. et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132:487-98 (2008).<\/p>\n

2. Mort, R. L. et al. Fucci2a: A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice. Cell Cycle 13, (2014).<\/p>\n

3. Sakaue-Sawano A. et al. Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle. Mol. Cell 2;68(3):626-640.e5 <\/span>(2017).<\/p>\n

4. Mort, R. L. et al. Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nat. Commun. 7, (2016).<\/p>\n

5. Boulter E. et al. Cyclic uniaxial mechanical stretching of cells using a LEGO\u00ae parts-based mechanical stretcher system. J Cell Sci 133 (1): jcs234666, (2020).<\/p>\n","protected":false},"excerpt":{"rendered":"

The Mort Lab are looking for self-funded MSc by Research (MRes) students to develop new DNA damage biosensors or to […]<\/p>\n","protected":false},"author":1209,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-323","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/users\/1209"}],"replies":[{"embeddable":true,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/comments?post=323"}],"version-history":[{"count":2,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323\/revisions"}],"predecessor-version":[{"id":325,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/posts\/323\/revisions\/325"}],"wp:attachment":[{"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/media?parent=323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/categories?post=323"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/wp.lancs.ac.uk\/mortlab\/wp-json\/wp\/v2\/tags?post=323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}