Publications

In Silico Toxicity Screening as a Tool for the Development of Sustainable Electronics, Exemplified with Organic Light-Emitting Electrochemical Cells. Sutar, P., McGrath, T., Lulla Ramrakhiyani, K., Somerton, C., Ashton, M., Harper, G., Halcovitch, N., Mort, R., Wright, K., Stowell, A., Bird, D., Young, R. & Hardy, J., 25/09/2024, In: ChemistrySelect. 9, 36, e20230168.
Evergene: an interactive webtool for large-scale gene-centric analysis of primary tumours. Anna Kenndy, Ella Richardson, Jonathan Higham, Panagiotis Kotsantis, Richard Mort, Barbara Bo-Ju Shih. Bioinformatics Advances, vbae092, https://doi.org/10.1093/bioadv/vbae092.
Modelling adhesion in stochastic and mean-field models of cell migration. Shahzeb Raja Noureen, Richard L. Mort, Christian A. Yates. arXiv:2404.10120.
A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma. Alexander E.P. Loftus, Marianna S. Romano, Anh Nguyen Phuong, Morwenna T. Muir, John C. Dawson, Lidia Avalle, Adam T. Douglas, Richard L. Mort, Adam Byron, Neil O. Carragher, Steven M. Pollard, Valerie G. Brunton, Margaret C. Frame. Developmental Cell – In press.
Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. Jon Riddell, Shahzeb Raja Noureen, Luigi Sedda, James D. Glover, William K. W. Ho, Connor A. Bain, Arianna Berbeglia, Helen Brown, Calum Anderson, Yuhang Chen,
Michael L. Crichton4, Christian A. Yates, Richard L. Mort, Denis J. Headon. PLoS Biol. 2023 Sep 25;21(9):e3002316. doi: 10.1371/journal.pbio.3002316.
A genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2 mediated recombination in the melanocyte lineage. Wilkinson, E.L., Brennan, L.C., Harrison, O.J., Crane-Smith, Z., Gautier, P., Keighren, M.A., Budd, P., Swaminathan, K., Machesky, L.M., Allinson, S.L., Jackson, I.J. and Mort, R.L. Pigment Cell Melanoma Res. 2022. doi: 10.1111/pcmr.13076.
The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. Galeb, H. A., Lamantia, A., Robson, A., König, K., Eichhorn, J., Baldock, S. J., Ashton, M. D., Baum, J. v., Mort, R. L., Robinson, B. J., Schacher, F. H., Chechik, V., Taylor, A. M., & Hardy, J. G. Macromolecular Chemistry and Physics, 2100489(2022). doi: 10.1002/macp.202100489
Fingerprinting of melanoblasts, melanocytes, melanoma cells and keratinocytes by live cell Raman spectroscopy reveals cell-type specific responses to UVR. Wilkinson EL, Ashton L, Kerns JG, Allinson SL, Mort RL. Exp Dermatol. 2022;00:1-11. doi: 10.1111/exd.14625
Swapping in lattice-based cell migration models. Noureen, S. R., Owen, J. P., Mort, R. L., & Yates, C. A. Phys Rev E. 2023 Apr;107(4-1):044402. doi: 10.1103/PhysRevE.107.044402.
Live Imaging and Analysis of Cilia and Cell Cycle Dynamics with the Arl13bCerulean-Fucci2a Biosensor and Fucci Tools.  Van Kerckvoorde M, Ford MJ, Yeyati PL, Mill P, Mort RL. Methods Mol Biol. 2021;2329:291-309. doi: 10.1007/978-1-0716-1538-6_21. PMID: 34085231
Melanins as Sustainable Resources for Advanced Biotechnological Applications.  Galeb HA, Wilkinson EL, Stowell AF, Lin H, Murphy ST, Martin-Hirsch PL, Mort RL, Taylor AM, Hardy JG. Glob Chall. 2020 Nov 25;5(2):2000102. doi: 10.1002/gch2.202000102. eCollection 2021 Feb. PMID: 33552556 Free PMC article. Review.
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M. Nat Cell Biol. 2019 Nov;21(11):1321-1333. doi: 10.1038/s41556-019-0402-6. Epub 2019 Nov 4. PMID: 31685987 Free PMC article.
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.  Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK. Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7. doi: 10.1016/j.stem.2019.07.008. Epub 2019 Aug 15. PMID: 31422913 Free PMC article.
Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.  Antonica F, Orietti LC, Mort RL, Zernicka-Goetz M. Dev Biol. 2019 Jun 15;450(2):132-140. doi: 10.1016/j.ydbio.2019.03.016. Epub 2019 Mar 30. PMID: 30940540 Free PMC article.
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.  Ford MJ, Yeyati PL, Mali GR, Keighren MA, Waddell SH, Mjoseng HK, Douglas AT, Hall EA, Sakaue-Sawano A, Miyawaki A, Meehan RR, Boulter L, Jackson IJ, Mill P, Mort RL. Dev Cell. 2018 Nov 19;47(4):509-523.e5. doi: 10.1016/j.devcel.2018.10.027. PMID: 30458140 Free PMC article.
The invasion speed of cell migration models with realistic cell cycle time distributions.  Gavagnin E, Ford MJ, Mort RL, Rogers T, Yates CA. J Theor Biol. 2019 Nov 21;481:91-99. doi: 10.1016/j.jtbi.2018.09.010. Epub 2018 Sep 14. PMID: 30219568
Computer simulation of neutral drift among limbal epithelial stem cells of mosaic mice.  West JD, Mort RL, Hill RE, Morley SD, Collinson JM. Stem Cell Res. 2018 Jul;30:1-11. doi: 10.1016/j.scr.2018.05.003. Epub 2018 May 13. PMID: 29777801 Free PMC article.
A Multi-stage Representation of Cell Proliferation as a Markov Process.  Yates CA, Ford MJ, Mort RL. Bull Math Biol. 2017 Dec;79(12):2905-2928. doi: 10.1007/s11538-017-0356-4. Epub 2017 Oct 13. PMID: 29030804 Free PMC article.
Hierarchical patterning modes orchestrate hair follicle morphogenesis. Glover JD, Wells KL, Matthäus F, Painter KJ, Ho W, Riddell J, Johansson JA, Ford MJ, Jahoda CAB, Klika V, Mort RL, Headon DJ. PLoS Biol. 2017 Jul 11;15(7):e2002117. doi: 10.1371/journal.pbio.2002117. eCollection 2017 Jul. PMID: 28700594 Free PMC article.
Using approximate Bayesian computation to quantify cell-cell adhesion parameters in a cell migratory process. Ross RJH, Baker RE, Parker A, Ford MJ, Mort RL, Yates CA. NPJ Syst Biol Appl. 2017 Mar 10;3:9. doi: 10.1038/s41540-017-0010-7. eCollection 2017. PMID: 28649436 Free PMC article.
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P. Am J Hum Genet. 2017 May 4;100(5):706-724. doi: 10.1016/j.ajhg.2017.03.008. Epub 2017 Apr 13. PMID: 28413018 Free PMC article.
Abnormal corneal epithelial maintenance in mice heterozygous for the micropinna microphthalmia mutation Mp. Douvaras P, Dorà NJ, Mort RL, Lodge EJ, Hill RE, West JD. Exp Eye Res. 2016 Aug;149:26-39. doi: 10.1016/j.exer.2016.05.021. Epub 2016 May 26. PMID: 27235794 Free PMC article.
Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Mort RL, Ross RJH, Hainey KJ, Harrison OJ, Keighren MA, Landini G, Baker RE, Painter KJ, Jackson IJ, Yates CA. Nat Commun. 2016 Jan 6;7:10288. doi: 10.1038/ncomms10288. PMID: 26732977 Free PMC article.
Maintenance of distinct melanocyte populations in the interfollicular epidermis. Glover JD, Knolle S, Wells KL, Liu D, Jackson IJ, Mort RL, Headon DJ. Pigment Cell Melanoma Res. 2015 Jul;28(4):476-80. doi: 10.1111/pcmr.12375. Epub 2015 Apr 30. PMID: 25847135 Free PMC article.
The melanocyte lineage in development and disease. Mort RL, Jackson IJ, Patton EE. Development. 2015 Apr 1;142(7):1387. doi: 10.1242/dev.123729. PMID: 25804742 Free PMC article. No abstract available.
The melanocyte lineage in development and disease. Mort RL, Jackson IJ, Patton EE. Development. 2015 Feb 15;142(4):620-32. doi: 10.1242/dev.106567. PMID: 25670789 Free PMC article. Review.
Fucci2a: a bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice. Mort RL, Ford MJ, Sakaue-Sawano A, Lindstrom NO, Casadio A, Douglas AT, Keighren MA, Hohenstein P, Miyawaki A, Jackson IJ. Cell Cycle. 2014;13(17):2681-96. doi: 10.4161/15384101.2015.945381. PMID: 25486356 Free PMC article.
Ex vivo culture of mouse embryonic skin and live-imaging of melanoblast migration. Mort RL, Keighren M, Hay L, Jackson IJ. J Vis Exp. 2014 May 19;(87):51352. doi: 10.3791/51352. PMID: 24894489 Free PMC article.
Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia. Douvaras P, Mort RL, Edwards D, Ramaesh K, Dhillon B, Morley SD, Hill RE, West JD. PLoS One. 2013 Aug 13;8(8):e71117. doi: 10.1371/journal.pone.0071117. eCollection 2013. PMID: 23967157 Free PMC article.
A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.  Jadeja S, Mort RL, Keighren M, Hart AW, Joynson R, Wells S, Potter PK, Jackson IJ. Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3569-78. doi: 10.1167/iovs.12-11125. PMID: 23633653 Free PMC article.
Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models.  Mort RL, Douvaras P, Morley SD, Dorà N, Hill RE, Collinson JM, West JD. Results Probl Cell Differ. 2012;55:357-94. doi: 10.1007/978-3-642-30406-4_19. PMID: 22918816 Free PMC article. Review.
Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism. Li A, Ma Y, Jin M, Mason S, Mort RL, Blyth K, Larue L, Sansom OJ, Machesky LM. J Invest Dermatol. 2012 Nov;132(11):2610-21. doi: 10.1038/jid.2012.186. Epub 2012 Jun 21. PMID: 22718121 Free PMC article.
Normal X-inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice–a model of human filamin A (FLNA) diseases. Douvaras P, Liu W, Mort RL, McKie L, West KM, Cross SH, Morley SD, West JD. BMC Res Notes. 2012 Feb 27;5:122. doi: 10.1186/1756-0500-5-122. PMID: 22369496 Free PMC article.
Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. Kucerova R, Dorà N, Mort RL, Wallace K, Leiper LJ, Lowes C, Neves C, Walczysko P, Bruce F, Fowler PA, Rajnicek AM, McCaig CD, Zhao M, West JD, Collinson JM. Mol Vis. 2012;18:139-50. Epub 2012 Jan 18. PMID: 22275805 Free PMC article.
Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis. Mort RL, Bentley AJ, Martin FL, Collinson JM, Douvaras P, Hill RE, Morley SD, Fullwood NJ, West JD. PLoS One. 2011;6(12):e28895. doi: 10.1371/journal.pone.0028895. Epub 2011 Dec 29. PMID: 22220198 Free PMC article.
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. PMID: 22109529 Free PMC article.
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Dev Cell. 2011 Oct 18;21(4):722-34. doi: 10.1016/j.devcel.2011.07.008. Epub 2011 Sep 15. PMID: 21924960 Free PMC article.
Ex vivo live imaging of melanoblast migration in embryonic mouse skin. Mort RL, Hay L, Jackson IJ. Pigment Cell Melanoma Res. 2010 Apr;23(2):299-301. doi: 10.1111/j.1755-148X.2010.00669.x. Epub 2010 Jan 7. PMID: 20067551 Free PMC article. No abstract available.
Quantitative analysis of patch patterns in mosaic tissues with ClonalTools software.  Mort RL. J Anat. 2009 Dec;215(6):698-704. doi: 10.1111/j.1469-7580.2009.01150.x. Epub 2009 Oct 13. PMID: 19840025 Free PMC article.
Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium. Mort RL, Ramaesh T, Kleinjan DA, Morley SD, West JD. BMC Dev Biol. 2009 Jan 7;9:4. doi: 10.1186/1471-213X-9-4. PMID: 19128502 Free PMC article.